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Medications that inhibit CYP2D6 activity, for example paroxetine and quinidine, may perhaps cause lessened clearance of oxycodone which could lead on to a rise in oxycodone plasma concentrations. Concurrent administration of quinidine resulted in a rise in oxycodone Cmax by eleven%, AUC by 13%, and t½ elim.As with all opioid preparations, oxycodon